| Product: | Simvastatin | ||||||||
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| Catalog Number: | 4893 | ||||||||
| CAS Number: | 79902-63-9 | ||||||||
| Synonyms: | 2,2-Dimethylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl -8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; (+)-Simvastatin; Cholestat; Lipex; Novo-Simvastatin; Simvotin; Sinvacor; Statin; Zocor; Zorced | ||||||||
| Pricing: |
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| Formula: | C25H38O5 | ||||||||
| Molecular Weight: | 418.57 | ||||||||
| Structure: |  | ||||||||
| Appearance: | White powder | ||||||||
| Category: | API Compounds | ||||||||
| Stability: | Stable under recommended storage conditions. | ||||||||
| Storage: | Store as supplied, at -20° C for up to 1 year. Store solutions at -20° C for up to 3 months | ||||||||
| Transportation: | Non-hazardous for transport | ||||||||
| Literature References: | Nègre-Aminou, P., et al. 1997. Biochim. Biophys. Acta. 1345: 259-268. PMID: 9150246;Wójcik, C., et al. 2000. Int. J. Biochem. Cell Biol. 32: 957-965. PMID: 11084375;Danesh, F.R., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 8301-8305. PMID: 12048257;Blanco-Colio, L.M., et al. 2003. Kidney Int. 63: 12-23. PMID: 12472764;Chopra, V., et al. 2007. Cardiovasc Drugs Ther. 21: 161-169. PMID: 17468937;Wang, H., et al. 2007. Exp. Neurol. 206: 59-69. PMID: 17521631 | ||||||||
| MSDS: | Click here. | ||||||||
| Description: | Simvastatin is an 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho GTPase/p21 signaling in mesangial cells | ||||||||
| Applications: | A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic |
