Product: | Amitriptyline HCl | ||||
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Catalog Number: | 16820 | ||||
CAS Number: | 549-18-8 | ||||
Pricing: |
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Formula: | C20H23N • HCl | ||||
Chemical Purity: | >98% | ||||
Molecular Weight: | 313.87 | ||||
Structure: | |||||
Appearance: | White powder | ||||
Category: | Biochemicals and Reagents | ||||
Stability: | Stable under recommended storage conditions. | ||||
Storage: | Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C | ||||
Transportation: | IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solid, organic, n.o.s. (Amitriptyline hydrochloride) | ||||
Literature References: | Kabir-ud-Din, , et al., Self-association Behavior Of Amitriptyline Hydrochloride As A Function Of Temperature And Additive (inorganic Salts And Ureas) Concentration. Colloids Surf., B 82, 87-94, (2011); Huangfu, D., et al., Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats. Am. J. Physiol. 268, R1429-R1441, (1995); Teschemacher, A.G., et al., Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. Br. J. Pharmacol. 128, 479-485, (1999); Stanton, T., et al., Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochem. Pharmacol. 45, 2352-2354, (1993); Sanchez, C., and Hyttel, J., Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell. Mol. Neurobiol. 19, 467-489, (1999); Torres, G.E., et al., Plasma membrane monoamine transporter: structure, regulation and function. Nat. Rev. Neurosci. 4, 13-25, (2003); Merck 14,487 | ||||
MSDS: | |||||
Description: | Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors. |