| Product: | Cyclosporin A | ||||||||
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| Catalog Number: | 8709 | ||||||||
| CAS Number: | 59865-13-3 | ||||||||
| Synonyms: | Cyclosporine; Ciclosporin; Atopica; Sandimmun(e); Neoral; Optimmune; Restasis | ||||||||
| Pricing: |
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| Formula: | C62H111N11O12 | ||||||||
| Chemical Purity: | 98.5% | ||||||||
| Molecular Weight: | 1202.61 | ||||||||
| Structure: |  | ||||||||
| Appearance: | White solid | ||||||||
| Category: | Antibiotics | ||||||||
| Stability: | Stable under recommended storage conditions | ||||||||
| Storage: | Keep container tightly closed in a dry and well-ventilated place. Store at: 2-8°C | ||||||||
| Transportation: | Non-hazardous for transport | ||||||||
| Literature References: | Donjerkovic, et al., Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium. Cell. Growth Differ., 1999, 10:695-704.; Mordvinov, et al., A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. J. Immunol. Methods, 1999, 228:163-168.; Zaidan, et al., Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J. Neurochem., 1999, 73:2214-2217.; Pritchard, D.E., et al., Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis, 2000, 21:2027-2033. | ||||||||
| MSDS: | Click here. | ||||||||
| Description: | A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria |
