| Product: | Daunorubicin • HCl | ||||||||
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| Catalog Number: | 17438 | ||||||||
| CAS Number: | 23541-50-6 | ||||||||
| Synonyms: | Daunorubicin hydrochloride; Daunomycin hydrochloride | ||||||||
| Pricing: |
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| Formula: | C27H29NO10 • HCl | ||||||||
| Molecular Weight: | 563.98 | ||||||||
| Structure: |  | ||||||||
| Appearance: | Solid | ||||||||
| Category: | Anti-cancer compounds | ||||||||
| Stability: | Stable under recommended storage conditions. | ||||||||
| Storage: | Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C. | ||||||||
| Transportation: | IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solid, organic, n.o.s. (Daunorubicin hydrochloride) | ||||||||
| Literature References: | Gong, Y. et al. J. Biol. Chem. 278, 50234-50239, (2003);Wang, E.J., et al. Drug Metab. Dispos. 28, 522-528, (2000); Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975); Munger, C., et al., Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatoma. Cancer Res. 48, 2404-2411, (1988); Schelling, J.A.A., et al. Eur. J. Biochem. 102, 409, (1979); Chaires, J.B. Nucleic Acids Res. 11, 8485, (1983); White, R.J., et al. Drugs Pharm. Sci. 22, 569, (1984); Merck 14,2832 | ||||||||
| MSDS: | |||||||||
| Description: | Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.1,2 Strong inhibitor of DNA and RNA synthesis. Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. Properties |
