| Product: | Annonacin | ||||||||
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| Catalog Number: | 17345 | ||||||||
| CAS Number: | 111035-65-5 | ||||||||
| Pricing: |
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| Molecular Weight: | 596.88 | ||||||||
| Structure: |  | ||||||||
| Category: | Anti-cancer compounds | ||||||||
| Literature References: | Lannuzel, A.; Michel, P. P.; Höglinger, G. U.; Champy, P.; Jousset, A.; Medja, F.; Lombès, A.; Darios, F. et al., The Mitochondrial Complex I Inhibitor Annonacin is Toxic to Mesencephalic Dopaminergic Neurons by Impairment of Energy Metabolism. Neuroscience, 2003, 121 (2): 287–296.; Champy, P.; Höglinger, G. U.; Féger, J.; Gleye, C.; Hocquemiller, R.; Laurens, A.; Guérineau, V.; Laprévote, O. et al., Annonacin, a Lipophilic Inhibitor of Mitochondrial Complex I, induces Nigral and Striatal Neurodegeneration in Rats: Possible Relevance for Atypical Parkinsonism in Guadeloupe. Journal of Neurochemistry, 2003, 88 (1): 63–69.; McLaughlin, J. L.., Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products. Journal of Natural Products, 2008, 71(7): 1311–1321. | ||||||||
| MSDS: | Click here. | ||||||||
| Applications: | An acetogenin. Blocks mitochondrial complex I, which is responsible for the conversion of NADH to NAD+ and the build-up of the proton gradient. Disables a cell"s ability to genertate ATP leading to cell death. |
