| Product: | Amsacrine HCl | ||||||||
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| Catalog Number: | 17334 | ||||||||
| CAS Number: | 54301-15-4 | ||||||||
| Synonyms: | m-AMSA; 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-ansidinehydrochloride | ||||||||
| Pricing: |
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| Formula: | C21H19N3O3S • HCl | ||||||||
| Chemical Purity: | >98% | ||||||||
| Molecular Weight: | 429.92 | ||||||||
| Structure: |  | ||||||||
| Appearance: | Powder | ||||||||
| Category: | Anti-cancer compounds | ||||||||
| Stability: | Stable under recommended storage conditions | ||||||||
| Storage: | Keep container tightly closed in a dry and well-ventilated place. Light sensitive | ||||||||
| Transportation: | IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solid, organic, n.o.s. (Amsacrine hydrochloride) | ||||||||
| Literature References: | Davey, R.A., et al., The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro. Cancer Chemother. Pharmacol. 39, 424-430, (1997); Nelson, E.M., et al., Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4"-(9-acridinylamino)-methanesulfon-m-anisidide. Proc. Natl. Acad. Sci. U. S. A. 81, 1361-1365, (1984); Ferguson, L.R., , Application of fluorescence in situ hybridization to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. Environ. Mol. Mutagen. 27, 255, (1996); Mosesso, P., et al., Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. Mutagenesis 13, 39-43, (1998); Del Bino, G., et al., The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195, 485-491, (1991); Negri, C., et al., Induction of apoptotic cell death by DNA topoisomerase II inhibitors. Biochimie 77, 893-899, (1995) | ||||||||
| MSDS: | |||||||||
| Description: | Amsacrine hydrochloride is a DNA topoisomerase II inhibitor |
