| Product: | KN-62 | ||||||||
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| Catalog Number: | 11303 | ||||||||
| CAS Number: | 127191-97-3 | ||||||||
| Synonyms: | (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester; 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine | ||||||||
| Pricing: |
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| Formula: | C38H35O6S2 | ||||||||
| Chemical Purity: | >95% | ||||||||
| Molecular Weight: | 721.84 | ||||||||
| Structure: |  | ||||||||
| Appearance: | White powder | ||||||||
| Category: | Protein Kinase Inhibitors and Activators | ||||||||
| Stability: | Stable under recommended storage conditions. | ||||||||
| Storage: | Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. | ||||||||
| Transportation: | Non-hazardous for transport | ||||||||
| Literature References: | MacLeod, et al., Ca(2+)/Calmodulin kinase II and decreases in intracellular pH are required to activate K(+) channels after substantial swelling in villus epithelial cells. J. Membr. Biol. 172, 59-66, (1999); Fan, et al., Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol. Pharmacol. 56, 39-45, (1999); Communi, et al., Calcium-calmodulin-dependent protein kinase II and protein kinase C-mediated phosphorylation and activation of D-myo-inositol 145-trisphosphate 3-kinase B in astrocytes. J. Biol. Chem. 274, 14734-14742, (1999) | ||||||||
| MSDS: | |||||||||
| Description: | Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II. |
